TSPAN3-PLAT Fusion FISH Probe
The TSPAN3-PLAT Fusion FISH Probe is used to confirm a fusion of the TSPAN3 and PLAT genes. The fusion of the TSPAN3 and PLAT genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TSPAN3-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| TSPAN3-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
TSPAN3 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
Gene Name: Tetraspanin 3
Chromosome: CHR15: 77336359 -77363570
Locus: 15q24.3
Gene Diseases
The TSPAN3 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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