TSFM-CYP27B1 Fusion FISH Probe
The TSFM-CYP27B1 Fusion FISH Probe is used to confirm a fusion of the TSFM and CYP27B1 genes. The fusion of the TSFM and CYP27B1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TSFM-CYP27B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-RERE | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-REOR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-REGO | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-REGR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-REAQ | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-ORRE | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-OROR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-ORGO | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GORE | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GOOR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GOGO | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GOGR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GRRE | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GROR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GRGO | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GRGR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-AQRE | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-AQOR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-AQGO | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-AQGR | 20 (40 μL) | 200 μL |
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| TSFM-CYP27B1-20-AQAQ | 20 (40 μL) | 200 μL |
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CYP27B1 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome P450 Family 27 Subfamily B Member 1
Chromosome: CHR12: 58156116 -58160976
Locus: 12q14.1
TSFM Gene Summary
This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Gene Name: Ts Translation Elongation Factor, Mitochondrial
Chromosome: CHR12: 58176527 -58196639
Locus: 12q14.1
Gene Diseases
The TSFM CYP27B1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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