TSEN2-SYN2 Fusion FISH Probe
The TSEN2-SYN2 Fusion FISH Probe is used to confirm a fusion of the TSEN2 and SYN2 genes. The fusion of the TSEN2 and SYN2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TSEN2-SYN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-RERE | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-REOR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-REGO | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-REGR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-REAQ | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-ORRE | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-OROR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-ORGO | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GORE | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GOOR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GOGO | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GOGR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GRRE | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GROR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GRGO | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GRGR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-AQRE | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-AQOR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-AQGO | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-AQGR | 20 (40 μL) | 200 μL |
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| TSEN2-SYN2-20-AQAQ | 20 (40 μL) | 200 μL |
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SYN2 Gene Summary
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]
Gene Name: Synapsin II
Chromosome: CHR3: 12045861 -12233532
Locus: 3p25.2
TSEN2 Gene Summary
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Name: TRNA Splicing Endonuclease Subunit 2
Chromosome: CHR3: 12525930 -12574820
Locus: 3p25.2
Gene Diseases
The TSEN2 SYN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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