TSC22D1-LETM1 Fusion FISH Probe
The TSC22D1-LETM1 Fusion FISH Probe is used to confirm a fusion of the TSC22D1 and LETM1 genes. The fusion of the TSC22D1 and LETM1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TSC22D1-LETM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-RERE | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-REOR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-REGO | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-REGR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-REAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-ORRE | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-OROR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-ORGO | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GORE | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GOOR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GOGO | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GOGR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GRRE | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GROR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GRGO | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GRGR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-AQRE | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-AQOR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-AQGO | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-AQGR | 20 (40 μL) | 200 μL |
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| TSC22D1-LETM1-20-AQAQ | 20 (40 μL) | 200 μL |
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LETM1 Gene Summary
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
Gene Name: Leucine Zipper And EF-hand Containing Transmembrane Protein 1
Chromosome: CHR4: 1813205 -1857974
Locus: 4p16.3
TSC22D1 Gene Summary
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Name: TSC22 Domain Family Member 1
Chromosome: CHR13: 45006278 -45150701
Locus: 13q14.11
Gene Diseases
The TSC22D1 LETM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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