TSC22D1-EIF2AK2 Fusion FISH Probe
The TSC22D1-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the TSC22D1 and EIF2AK2 genes. The fusion of the TSC22D1 and EIF2AK2 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TSC22D1-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| TSC22D1-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
TSC22D1 Gene Summary
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Name: TSC22 Domain Family Member 1
Chromosome: CHR13: 45006278 -45150701
Locus: 13q14.11
Gene Diseases
The TSC22D1 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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