TSC2-MAPK8IP3 Fusion FISH Probe
The TSC2-MAPK8IP3 Fusion FISH Probe is used to confirm a fusion of the TSC2 and MAPK8IP3 genes. The fusion of the TSC2 and MAPK8IP3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TSC2-MAPK8IP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TSC2-MAPK8IP3-20-AQAQ | 20 (40 μL) | 200 μL |
|
TSC2 Gene Summary
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: TSC Complex Subunit 2
Chromosome: CHR16: 2097989 -2138713
Locus: 16p13.3
MAPK8IP3 Gene Summary
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase 8 Interacting Protein 3
Chromosome: CHR16: 1756220 -1820318
Locus: 16p13.3
Gene Diseases
The TSC2 MAPK8IP3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|