TRRAP-PRKAR2B Fusion FISH Probe
The TRRAP-PRKAR2B Fusion FISH Probe is used to confirm a fusion of the TRRAP and PRKAR2B genes. The fusion of the TRRAP and PRKAR2B genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRRAP-PRKAR2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-RERE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REOR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-REAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-ORRE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-OROR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-ORGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GORE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOOR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRRE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GROR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQRE | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQOR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQGO | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQGR | 20 (40 μL) | 200 μL |
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| TRRAP-PRKAR2B-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAR2B Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Beta
Chromosome: CHR7: 106685177 -106802256
Locus: 7q22.3
TRRAP Gene Summary
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Transformation/transcription Domain Associated Protein
Chromosome: CHR7: 98476112 -98610864
Locus: 7q22.1
Gene Diseases
The TRRAP PRKAR2B Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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