TRPV4-GIT2 Fusion FISH Probe
The TRPV4-GIT2 Fusion FISH Probe is used to confirm a fusion of the TRPV4 and GIT2 genes. The fusion of the TRPV4 and GIT2 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRPV4-GIT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TRPV4-GIT2-20-AQAQ | 20 (40 μL) | 200 μL |
|
GIT2 Gene Summary
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Gene Name: GIT ArfGAP 2
Chromosome: CHR12: 110367606 -110434194
Locus: 12q24.11
TRPV4 Gene Summary
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Name: Transient Receptor Potential Cation Channel Subfamily V Member 4
Chromosome: CHR12: 110220891 -110271212
Locus: 12q24.11
Gene Diseases
The TRPV4 GIT2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|