TRPC1-PTPRG Fusion FISH Probe
The TRPC1-PTPRG Fusion FISH Probe is used to confirm a fusion of the TRPC1 and PTPRG genes. The fusion of the TRPC1 and PTPRG genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRPC1-PTPRG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-RERE | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-REOR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-REGO | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-REGR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-REAQ | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-ORRE | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-OROR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-ORGO | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GORE | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GOOR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GOGO | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GOGR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GRRE | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GROR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GRGO | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GRGR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-AQRE | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-AQOR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-AQGO | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-AQGR | 20 (40 μL) | 200 μL |
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| TRPC1-PTPRG-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRG Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type G
Chromosome: CHR3: 61547242 -62280573
Locus: 3p14.2
TRPC1 Gene Summary
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Transient Receptor Potential Cation Channel Subfamily C Member 1
Chromosome: CHR3: 142443265 -142526729
Locus: 3q23
Gene Diseases
The TRPC1 PTPRG Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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