TRMU-PPARA Fusion FISH Probe
The TRMU-PPARA Fusion FISH Probe is used to confirm a fusion of the TRMU and PPARA genes. The fusion of the TRMU and PPARA genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRMU-PPARA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-RERE | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-REOR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-REGO | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-REGR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-REAQ | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-ORRE | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-OROR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-ORGO | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GORE | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GOOR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GOGO | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GOGR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GRRE | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GROR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GRGO | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GRGR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-AQRE | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-AQOR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-AQGO | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-AQGR | 20 (40 μL) | 200 μL |
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| TRMU-PPARA-20-AQAQ | 20 (40 μL) | 200 μL |
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PPARA Gene Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Gene Name: Peroxisome Proliferator Activated Receptor Alpha
Chromosome: CHR22: 46546498 -46639653
Locus: 22q13.31
TRMU Gene Summary
This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: TRNA 5-methylaminomethyl-2-thiouridylate Methyltransferase
Chromosome: CHR22: 46731297 -46753237
Locus: 22q13.31
Gene Diseases
The TRMU PPARA Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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