TRMU-ATXN10 Fusion FISH Probe
The TRMU-ATXN10 Fusion FISH Probe is used to confirm a fusion of the TRMU and ATXN10 genes. The fusion of the TRMU and ATXN10 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRMU-ATXN10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-RERE | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-REOR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-REGO | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-REGR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-REAQ | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-ORRE | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-OROR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-ORGO | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GORE | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GOOR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GOGO | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GOGR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GRRE | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GROR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GRGO | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GRGR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-AQRE | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-AQOR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-AQGO | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-AQGR | 20 (40 μL) | 200 μL |
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| TRMU-ATXN10-20-AQAQ | 20 (40 μL) | 200 μL |
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ATXN10 Gene Summary
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]
Gene Name: Ataxin 10
Chromosome: CHR22: 46067677 -46241187
Locus: 22q13.31
TRMU Gene Summary
This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: TRNA 5-methylaminomethyl-2-thiouridylate Methyltransferase
Chromosome: CHR22: 46731297 -46753237
Locus: 22q13.31
Gene Diseases
The TRMU ATXN10 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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