TRIP11-CYP46A1 Fusion FISH Probe
The TRIP11-CYP46A1 Fusion FISH Probe is used to confirm a fusion of the TRIP11 and CYP46A1 genes. The fusion of the TRIP11 and CYP46A1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIP11-CYP46A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-RERE | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-REOR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-REGO | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-REGR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-OROR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GORE | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GROR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIP11-CYP46A1-20-AQAQ | 20 (40 μL) | 200 μL |
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TRIP11 Gene Summary
This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
Gene Name: Thyroid Hormone Receptor Interactor 11
Chromosome: CHR14: 92434242 -92506403
Locus: 14q32.12
CYP46A1 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome P450 Family 46 Subfamily A Member 1
Chromosome: CHR14: 100150754 -100193638
Locus: 14q32.2
Gene Diseases
The TRIP11 CYP46A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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