TRIOBP-PES1 Fusion FISH Probe
The TRIOBP-PES1 Fusion FISH Probe is used to confirm a fusion of the TRIOBP and PES1 genes. The fusion of the TRIOBP and PES1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIOBP-PES1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-RERE | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-REOR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-REGO | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-REGR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-OROR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GORE | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GROR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIOBP-PES1-20-AQAQ | 20 (40 μL) | 200 μL |
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TRIOBP Gene Summary
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Gene Name: TRIO And F-actin Binding Protein
Chromosome: CHR22: 38092994 -38172563
Locus: 22q13.1
PES1 Gene Summary
This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]
Gene Name: Pescadillo Ribosomal Biogenesis Factor 1
Chromosome: CHR22: 30972611 -31003000
Locus: 22q12.2
Gene Diseases
The TRIOBP PES1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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