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TRIO-TERT Fusion FISH Probe

The TRIO-TERT Fusion FISH Probe is used to confirm a fusion of the TRIO and TERT genes. The fusion of the TRIO and TERT genes has been associated with Sarcoma, Sarcoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
TRIO-TERT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TRIO-TERT-20-RERE 20 (40 μL) 200 μL
TRIO-TERT-20-REOR 20 (40 μL) 200 μL
TRIO-TERT-20-REGO 20 (40 μL) 200 μL
TRIO-TERT-20-REGR 20 (40 μL) 200 μL
TRIO-TERT-20-REAQ 20 (40 μL) 200 μL
TRIO-TERT-20-ORRE 20 (40 μL) 200 μL
TRIO-TERT-20-OROR 20 (40 μL) 200 μL
TRIO-TERT-20-ORGO 20 (40 μL) 200 μL
TRIO-TERT-20-ORAQ 20 (40 μL) 200 μL
TRIO-TERT-20-GORE 20 (40 μL) 200 μL
TRIO-TERT-20-GOOR 20 (40 μL) 200 μL
TRIO-TERT-20-GOGO 20 (40 μL) 200 μL
TRIO-TERT-20-GOGR 20 (40 μL) 200 μL
TRIO-TERT-20-GOAQ 20 (40 μL) 200 μL
TRIO-TERT-20-GRRE 20 (40 μL) 200 μL
TRIO-TERT-20-GROR 20 (40 μL) 200 μL
TRIO-TERT-20-GRGO 20 (40 μL) 200 μL
TRIO-TERT-20-GRGR 20 (40 μL) 200 μL
TRIO-TERT-20-GRAQ 20 (40 μL) 200 μL
TRIO-TERT-20-AQRE 20 (40 μL) 200 μL
TRIO-TERT-20-AQOR 20 (40 μL) 200 μL
TRIO-TERT-20-AQGO 20 (40 μL) 200 μL
TRIO-TERT-20-AQGR 20 (40 μL) 200 μL
TRIO-TERT-20-AQAQ 20 (40 μL) 200 μL

TERT Gene Summary

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Gene Name: Telomerase Reverse Transcriptase

Chromosome: CHR5: 1253286 -1295162

Locus: 5p15.33

TRIO Gene Summary

This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Gene Name: Trio Rho Guanine Nucleotide Exchange Factor

Chromosome: CHR5: 14143828 -14509458

Locus: 5p15.2

Gene Diseases

The TRIO TERT Fusion has been associated with the following diseases:

Disease Name
Sarcoma
Sarcoma
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.

The TERT gene, which encodes a telomerase subunit, has long interested cancer researchers because it's required for cell proliferation and immortalization in 80-90% of human cancers. This study analyzed TERT expression across 10 human cancer lines using our TERT FISH probe. TERT expression was highly heterogeneous across different cancers, with variations in cellular location of the TERT protein, number of transcription sites, and ratio of transcription sites to gene copies.
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Analysis of mucosal melanoma whole-genome landscapes reveals clinically relevant genomic aberrations

Unlike cutaneous melanoma, the genomics of mucosal melanoma (MM) remain poorly understood, which has hindered the development of targeted therapy for MM patients. In order to account for this gap in data, this team performed whole-genome sequencing on 65 MM samples to identify genomic alterations with prognostic and/or therapeutic implications. Our CDK4 and TERT probes were used to detect amplification of the genes.
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