TRIO-LIFR Fusion FISH Probe
The TRIO-LIFR Fusion FISH Probe is used to confirm a fusion of the TRIO and LIFR genes. The fusion of the TRIO and LIFR genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRIO-LIFR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-LIFR-20-AQAQ | 20 (40 μL) | 200 μL |
|
LIFR Gene Summary
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: LIF Receptor Alpha
Chromosome: CHR5: 38475064 -38595507
Locus: 5p13.1
TRIO Gene Summary
This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Trio Rho Guanine Nucleotide Exchange Factor
Chromosome: CHR5: 14143828 -14509458
Locus: 5p15.2
Gene Diseases
The TRIO LIFR Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|