TRIO-FBXL7 Fusion FISH Probe
The TRIO-FBXL7 Fusion FISH Probe is used to confirm a fusion of the TRIO and FBXL7 genes. The fusion of the TRIO and FBXL7 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRIO-FBXL7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TRIO-FBXL7-20-AQAQ | 20 (40 μL) | 200 μL |
|
TRIO Gene Summary
This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Trio Rho Guanine Nucleotide Exchange Factor
Chromosome: CHR5: 14143828 -14509458
Locus: 5p15.2
FBXL7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: F-box And Leucine Rich Repeat Protein 7
Chromosome: CHR5: 15500304 -15939900
Locus: 5p15.1
Gene Diseases
The TRIO FBXL7 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|