TRIM33-SHC1 Fusion FISH Probe
The TRIM33-SHC1 Fusion FISH Probe is used to confirm a fusion of the TRIM33 and SHC1 genes. The fusion of the TRIM33 and SHC1 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIM33-SHC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-RERE | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-REOR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-REGO | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-REGR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-OROR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GORE | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GROR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIM33-SHC1-20-AQAQ | 20 (40 μL) | 200 μL |
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SHC1 Gene Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: SHC Adaptor Protein 1
Chromosome: CHR1: 154934773 -154946959
Locus: 1q21.3
TRIM33 Gene Summary
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Tripartite Motif Containing 33
Chromosome: CHR1: 114935398 -115053781
Locus: 1p13.2
Gene Diseases
The TRIM33 SHC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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