TRIM33-BCAR3 Fusion FISH Probe
The TRIM33-BCAR3 Fusion FISH Probe is used to confirm a fusion of the TRIM33 and BCAR3 genes. The fusion of the TRIM33 and BCAR3 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIM33-BCAR3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-RERE | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-REOR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-REGO | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-REGR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-OROR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GORE | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GROR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIM33-BCAR3-20-AQAQ | 20 (40 μL) | 200 μL |
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BCAR3 Gene Summary
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: BCAR3, NSP Family Adaptor Protein
Chromosome: CHR1: 94027348 -94147385
Locus: 1p22.1
TRIM33 Gene Summary
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Tripartite Motif Containing 33
Chromosome: CHR1: 114935398 -115053781
Locus: 1p13.2
Gene Diseases
The TRIM33 BCAR3 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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