TRIM27-RET Fusion FISH Probe
The TRIM27-RET Fusion FISH Probe is used to confirm a fusion of the TRIM27 and RET genes. The fusion of the TRIM27 and RET genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIM27-RET-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-RERE | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-REOR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-REGO | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-REGR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-OROR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GORE | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GROR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIM27-RET-20-AQAQ | 20 (40 μL) | 200 μL |
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RET Gene Summary
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Gene Name: Ret Proto-oncogene
Chromosome: CHR10: 43572516 -43625797
Locus: 10q11.21
TRIM27 Gene Summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Gene Name: Tripartite Motif Containing 27
Chromosome: CHR6_cox_hap2: 393802 -414796
Locus: 6p22.1
Gene Diseases
The TRIM27 RET Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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