TRIM2-LRBA Fusion FISH Probe
The TRIM2-LRBA Fusion FISH Probe is used to confirm a fusion of the TRIM2 and LRBA genes. The fusion of the TRIM2 and LRBA genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIM2-LRBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-RERE | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-REOR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-REGO | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-REGR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-OROR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GORE | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GROR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIM2-LRBA-20-AQAQ | 20 (40 μL) | 200 μL |
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LRBA Gene Summary
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: LPS Responsive Beige-like Anchor Protein
Chromosome: CHR4: 151185810 -151936649
Locus: 4q31.3
TRIM2 Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Gene Name: Tripartite Motif Containing 2
Chromosome: CHR4: 154074269 -154260474
Locus: 4q31.3
Gene Diseases
The TRIM2 LRBA Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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