TRIB3-DEFB125 Fusion FISH Probe
The TRIB3-DEFB125 Fusion FISH Probe is used to confirm a fusion of the TRIB3 and DEFB125 genes. The fusion of the TRIB3 and DEFB125 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIB3-DEFB125-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-RERE | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-REOR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-REGO | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-REGR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-OROR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GORE | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GROR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIB3-DEFB125-20-AQAQ | 20 (40 μL) | 200 μL |
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TRIB3 Gene Summary
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: Tribbles Pseudokinase 3
Chromosome: CHR20: 361307 -378203
Locus: 20p13
DEFB125 Gene Summary
Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Gene Name: Defensin Beta 125
Chromosome: CHR20: 68350 -77296
Locus: 20p13
Gene Diseases
The TRIB3 DEFB125 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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