TRAP1-CREBBP Fusion FISH Probe
The TRAP1-CREBBP Fusion FISH Probe is used to confirm a fusion of the TRAP1 and CREBBP genes. The fusion of the TRAP1 and CREBBP genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAP1-CREBBP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-RERE | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-REOR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-REGO | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-REGR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-OROR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GORE | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GROR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAP1-CREBBP-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBBP Gene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Name: CREB Binding Protein
Chromosome: CHR16: 3775055 -3930121
Locus: 16p13.3
TRAP1 Gene Summary
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Name: TNF Receptor Associated Protein 1
Chromosome: CHR16: 3708037 -3767598
Locus: 16p13.3
Gene Diseases
The TRAP1 CREBBP Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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