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TRAF4-FASN Fusion FISH Probe

The TRAF4-FASN Fusion FISH Probe is used to confirm a fusion of the TRAF4 and FASN genes. The fusion of the TRAF4 and FASN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TRAF4-FASN-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TRAF4-FASN-20-RERE 20 (40 μL) 200 μL
TRAF4-FASN-20-REOR 20 (40 μL) 200 μL
TRAF4-FASN-20-REGO 20 (40 μL) 200 μL
TRAF4-FASN-20-REGR 20 (40 μL) 200 μL
TRAF4-FASN-20-REAQ 20 (40 μL) 200 μL
TRAF4-FASN-20-ORRE 20 (40 μL) 200 μL
TRAF4-FASN-20-OROR 20 (40 μL) 200 μL
TRAF4-FASN-20-ORGO 20 (40 μL) 200 μL
TRAF4-FASN-20-ORAQ 20 (40 μL) 200 μL
TRAF4-FASN-20-GORE 20 (40 μL) 200 μL
TRAF4-FASN-20-GOOR 20 (40 μL) 200 μL
TRAF4-FASN-20-GOGO 20 (40 μL) 200 μL
TRAF4-FASN-20-GOGR 20 (40 μL) 200 μL
TRAF4-FASN-20-GOAQ 20 (40 μL) 200 μL
TRAF4-FASN-20-GRRE 20 (40 μL) 200 μL
TRAF4-FASN-20-GROR 20 (40 μL) 200 μL
TRAF4-FASN-20-GRGO 20 (40 μL) 200 μL
TRAF4-FASN-20-GRGR 20 (40 μL) 200 μL
TRAF4-FASN-20-GRAQ 20 (40 μL) 200 μL
TRAF4-FASN-20-AQRE 20 (40 μL) 200 μL
TRAF4-FASN-20-AQOR 20 (40 μL) 200 μL
TRAF4-FASN-20-AQGO 20 (40 μL) 200 μL
TRAF4-FASN-20-AQGR 20 (40 μL) 200 μL
TRAF4-FASN-20-AQAQ 20 (40 μL) 200 μL

FASN Gene Summary

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

Gene Name: Fatty Acid Synthase

Chromosome: CHR17: 80036213 -80056106

Locus: 17q25.3

TRAF4 Gene Summary

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Gene Name: TNF Receptor Associated Factor 4

Chromosome: CHR17: 27071022 -27077976

Locus: 17q11.2

Gene Diseases

The TRAF4 FASN Fusion has been associated with the following diseases:

Disease Name
Brain Lower Grade Glioma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.