TRAF3IP2-FYN Fusion FISH Probe
The TRAF3IP2-FYN Fusion FISH Probe is used to confirm a fusion of the TRAF3IP2 and FYN genes. The fusion of the TRAF3IP2 and FYN genes has been associated with Lung Squamous Cell Carcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAF3IP2-FYN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-RERE | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-REOR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-REGO | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-REGR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-OROR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GORE | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GROR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAF3IP2-FYN-20-AQAQ | 20 (40 μL) | 200 μL |
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FYN Gene Summary
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Gene Name: FYN Proto-oncogene, Src Family Tyrosine Kinase
Chromosome: CHR6: 111981534 -112194655
Locus: 6q21
TRAF3IP2 Gene Summary
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
Gene Name: TRAF3 Interacting Protein 2
Chromosome: CHR6: 111880142 -111927474
Locus: 6q21
Gene Diseases
The TRAF3IP2 FYN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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