TRAF3-CDC42BPB Fusion FISH Probe
The TRAF3-CDC42BPB Fusion FISH Probe is used to confirm a fusion of the TRAF3 and CDC42BPB genes. The fusion of the TRAF3 and CDC42BPB genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAF3-CDC42BPB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-RERE | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-REOR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-REGO | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-REGR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-OROR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GORE | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GROR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAF3-CDC42BPB-20-AQAQ | 20 (40 μL) | 200 μL |
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TRAF3 Gene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]
Gene Name: TNF Receptor Associated Factor 3
Chromosome: CHR14: 103243815 -103377837
Locus: 14q32.32
CDC42BPB Gene Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Gene Name: CDC42 Binding Protein Kinase Beta
Chromosome: CHR14: 103398715 -103523742
Locus: 14q32.32
Gene Diseases
The TRAF3 CDC42BPB Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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