TRAF3-BMP3 Fusion FISH Probe
The TRAF3-BMP3 Fusion FISH Probe is used to confirm a fusion of the TRAF3 and BMP3 genes. The fusion of the TRAF3 and BMP3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAF3-BMP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-RERE | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-REOR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-REGO | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-REGR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-OROR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GORE | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GROR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAF3-BMP3-20-AQAQ | 20 (40 μL) | 200 μL |
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BMP3 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016]
Gene Name: Bone Morphogenetic Protein 3
Chromosome: CHR4: 81952118 -81978685
Locus: 4q21.21
TRAF3 Gene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]
Gene Name: TNF Receptor Associated Factor 3
Chromosome: CHR14: 103243815 -103377837
Locus: 14q32.32
Gene Diseases
The TRAF3 BMP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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