TRAF2-MAMDC4 Fusion FISH Probe
The TRAF2-MAMDC4 Fusion FISH Probe is used to confirm a fusion of the TRAF2 and MAMDC4 genes. The fusion of the TRAF2 and MAMDC4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAF2-MAMDC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-RERE | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-REOR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-REGO | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-REGR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-OROR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GORE | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GROR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAF2-MAMDC4-20-AQAQ | 20 (40 μL) | 200 μL |
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TRAF2 Gene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
Gene Name: TNF Receptor Associated Factor 2
Chromosome: CHR9: 139780964 -139821067
Locus: 9q34.3
MAMDC4 Gene Summary
The MAM Domain Containing 4 (MAMDC4) gene is located on chr9 :139746818-139755251 at 9q34.3.
Gene Name: MAM Domain Containing 4
Chromosome: CHR9: 139746818 -139755251
Locus: 9q34.3
Gene Diseases
The TRAF2 MAMDC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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