TRAF2-CACNA1B Fusion FISH Probe
The TRAF2-CACNA1B Fusion FISH Probe is used to confirm a fusion of the TRAF2 and CACNA1B genes. The fusion of the TRAF2 and CACNA1B genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAF2-CACNA1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-RERE | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-REOR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-REGO | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-REGR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-OROR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GORE | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GROR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAF2-CACNA1B-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1B Gene Summary
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 B
Chromosome: CHR9: 140772240 -141019076
Locus: 9q34.3
TRAF2 Gene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
Gene Name: TNF Receptor Associated Factor 2
Chromosome: CHR9: 139780964 -139821067
Locus: 9q34.3
Gene Diseases
The TRAF2 CACNA1B Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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