TPX2-DEFB123 Fusion FISH Probe
The TPX2-DEFB123 Fusion FISH Probe is used to confirm a fusion of the TPX2 and DEFB123 genes. The fusion of the TPX2 and DEFB123 genes has been associated with Breast Invasive Carcinoma, Uterine Corpus Endometrial Carcinoma, Uterine Carcinosarcoma, and Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPX2-DEFB123-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-RERE | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-REOR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-REGO | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-REGR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-REAQ | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-ORRE | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-OROR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-ORGO | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GORE | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GOOR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GOGO | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GOGR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GRRE | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GROR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GRGO | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GRGR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-AQRE | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-AQOR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-AQGO | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-AQGR | 20 (40 μL) | 200 μL |
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| TPX2-DEFB123-20-AQAQ | 20 (40 μL) | 200 μL |
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TPX2 Gene Summary
The TPX2, Microtubule Nucleation Factor (TPX2) gene is located on chr20 :30326903-30389603 at 20q11.21.
Gene Name: TPX2, Microtubule Nucleation Factor
Chromosome: CHR20: 30326903 -30389603
Locus: 20q11.21
DEFB123 Gene Summary
Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20q11.1. Two transcript variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2014]
Gene Name: Defensin Beta 123
Chromosome: CHR20: 30028410 -30038060
Locus: 20q11.21
Gene Diseases
The TPX2 DEFB123 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Uterine Carcinosarcoma |
| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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