TPX2-COX4I2 Fusion FISH Probe
The TPX2-COX4I2 Fusion FISH Probe is used to confirm a fusion of the TPX2 and COX4I2 genes. The fusion of the TPX2 and COX4I2 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPX2-COX4I2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-RERE | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-REOR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-REGO | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-REGR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-REAQ | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-ORRE | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-OROR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-ORGO | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GORE | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GOOR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GOGO | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GOGR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GRRE | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GROR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GRGO | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GRGR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-AQRE | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-AQOR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-AQGO | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-AQGR | 20 (40 μL) | 200 μL |
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| TPX2-COX4I2-20-AQAQ | 20 (40 μL) | 200 μL |
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TPX2 Gene Summary
The TPX2, Microtubule Nucleation Factor (TPX2) gene is located on chr20 :30326903-30389603 at 20q11.21.
Gene Name: TPX2, Microtubule Nucleation Factor
Chromosome: CHR20: 30326903 -30389603
Locus: 20q11.21
COX4I2 Gene Summary
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome C Oxidase Subunit 4I2
Chromosome: CHR20: 30225690 -30232800
Locus: 20q11.21
Gene Diseases
The TPX2 COX4I2 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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