TPT1-NCALD Fusion FISH Probe
The TPT1-NCALD Fusion FISH Probe is used to confirm a fusion of the TPT1 and NCALD genes. The fusion of the TPT1 and NCALD genes has been associated with Breast Invasive Carcinoma, and Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPT1-NCALD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-RERE | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-REOR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-REGO | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-REGR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-REAQ | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-ORRE | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-OROR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-ORGO | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GORE | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GOOR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GOGO | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GOGR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GRRE | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GROR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GRGO | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GRGR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-AQRE | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-AQOR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-AQGO | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-AQGR | 20 (40 μL) | 200 μL |
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| TPT1-NCALD-20-AQAQ | 20 (40 μL) | 200 μL |
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TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
NCALD Gene Summary
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Neurocalcin Delta
Chromosome: CHR8: 102698769 -103137135
Locus: 8q22.3
Gene Diseases
The TPT1 NCALD Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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