TPT1-MYH9 Fusion FISH Probe
The TPT1-MYH9 Fusion FISH Probe is used to confirm a fusion of the TPT1 and MYH9 genes. The fusion of the TPT1 and MYH9 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPT1-MYH9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-RERE | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-REOR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-REGO | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-REGR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-REAQ | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-ORRE | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-OROR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-ORGO | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GORE | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GOOR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GOGO | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GOGR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GRRE | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GROR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GRGO | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GRGR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-AQRE | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-AQOR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-AQGO | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-AQGR | 20 (40 μL) | 200 μL |
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| TPT1-MYH9-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH9 Gene Summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Heavy Chain 9
Chromosome: CHR22: 36677322 -36784063
Locus: 22q12.3
TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
Gene Diseases
The TPT1 MYH9 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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