TPT1-MME Fusion FISH Probe
The TPT1-MME Fusion FISH Probe is used to confirm a fusion of the TPT1 and MME genes. The fusion of the TPT1 and MME genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPT1-MME-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-RERE | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-REOR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-REGO | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-REGR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-REAQ | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-ORRE | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-OROR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-ORGO | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GORE | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GOOR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GOGO | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GOGR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GRRE | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GROR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GRGO | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GRGR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-AQRE | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-AQOR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-AQGO | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-AQGR | 20 (40 μL) | 200 μL |
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| TPT1-MME-20-AQAQ | 20 (40 μL) | 200 μL |
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MME Gene Summary
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
Gene Name: Membrane Metalloendopeptidase
Chromosome: CHR3: 154797435 -154901518
Locus: 3q25.2
TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
Gene Diseases
The TPT1 MME Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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