TPT1-ERBB3 Fusion FISH Probe
The TPT1-ERBB3 Fusion FISH Probe is used to confirm a fusion of the TPT1 and ERBB3 genes. The fusion of the TPT1 and ERBB3 genes has been associated with Head And Neck Squamous Cell Carcinoma , and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPT1-ERBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-RERE | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-REOR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-REGO | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-REGR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-REAQ | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-ORRE | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-OROR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-ORGO | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GORE | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GOOR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GOGO | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GOGR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GRRE | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GROR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GRGO | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GRGR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-AQRE | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-AQOR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-AQGO | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-AQGR | 20 (40 μL) | 200 μL |
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| TPT1-ERBB3-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
Gene Diseases
The TPT1 ERBB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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