TPT1-EIF2AK2 Fusion FISH Probe
The TPT1-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the TPT1 and EIF2AK2 genes. The fusion of the TPT1 and EIF2AK2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPT1-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| TPT1-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
Gene Diseases
The TPT1 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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