TPT1-ARFGEF2 Fusion FISH Probe
The TPT1-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the TPT1 and ARFGEF2 genes. The fusion of the TPT1 and ARFGEF2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPT1-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| TPT1-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The TPT1 ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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