TPM4-IGFL2 Fusion FISH Probe
The TPM4-IGFL2 Fusion FISH Probe is used to confirm a fusion of the TPM4 and IGFL2 genes. The fusion of the TPM4 and IGFL2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPM4-IGFL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-RERE | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-REOR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-REGO | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-REGR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-REAQ | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-ORRE | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-OROR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-ORGO | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GORE | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GOOR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GOGO | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GOGR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GRRE | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GROR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GRGO | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GRGR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-AQRE | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-AQOR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-AQGO | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-AQGR | 20 (40 μL) | 200 μL |
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| TPM4-IGFL2-20-AQAQ | 20 (40 μL) | 200 μL |
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TPM4 Gene Summary
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Name: Tropomyosin 4
Chromosome: CHR19: 16178316 -16213813
Locus: 19p13.12-p13.11
IGFL2 Gene Summary
IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Gene Name: IGF Like Family Member 2
Chromosome: CHR19: 46651038 -46664561
Locus: 19q13.32
Gene Diseases
The TPM4 IGFL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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