TPM3-NTRK1 Fusion FISH Probe
The TPM3-NTRK1 Fusion FISH Probe is used to confirm a fusion of the TPM3 and NTRK1 genes. The fusion of the TPM3 and NTRK1 genes has been associated with Sarcoma, and Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TPM3-NTRK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TPM3-NTRK1-20-AQAQ | 20 (40 μL) | 200 μL |
|
NTRK1 Gene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 1
Chromosome: CHR1: 156785541 -156851642
Locus: 1q23.1
TPM3 Gene Summary
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Tropomyosin 3
Chromosome: CHR1: 154134289 -154164609
Locus: 1q21.3
Gene Diseases
The TPM3 NTRK1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|