TP53BP1-DAPK2 Fusion FISH Probe
The TP53BP1-DAPK2 Fusion FISH Probe is used to confirm a fusion of the TP53BP1 and DAPK2 genes. The fusion of the TP53BP1 and DAPK2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TP53BP1-DAPK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TP53BP1-DAPK2-20-AQAQ | 20 (40 μL) | 200 μL |
|
TP53BP1 Gene Summary
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein P53 Binding Protein 1
Chromosome: CHR15: 43699411 -43802707
Locus: 15q15.3
DAPK2 Gene Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Gene Name: Death Associated Protein Kinase 2
Chromosome: CHR15: 64199234 -64338521
Locus: 15q22.31
Gene Diseases
The TP53BP1 DAPK2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|