TP53-CHD3 Fusion FISH Probe
The TP53-CHD3 Fusion FISH Probe is used to confirm a fusion of the TP53 and CHD3 genes. The fusion of the TP53 and CHD3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TP53-CHD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-RERE | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-REOR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-REGO | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-REGR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-REAQ | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-ORRE | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-OROR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-ORGO | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GORE | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GOOR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GOGO | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GOGR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GRRE | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GROR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GRGO | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GRGR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-AQRE | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-AQOR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-AQGO | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-AQGR | 20 (40 μL) | 200 μL |
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| TP53-CHD3-20-AQAQ | 20 (40 μL) | 200 μL |
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CHD3 Gene Summary
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Chromodomain Helicase DNA Binding Protein 3
Chromosome: CHR17: 7788122 -7816075
Locus: 17p13.1
TP53 Gene Summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Gene Name: Tumor Protein P53
Chromosome: CHR17: 7571719 -7590863
Locus: 17p13.1
Gene Diseases
The TP53 CHD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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