TOX3-HEYL Fusion FISH Probe
The TOX3-HEYL Fusion FISH Probe is used to confirm a fusion of the TOX3 and HEYL genes. The fusion of the TOX3 and HEYL genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOX3-HEYL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-RERE | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-REOR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-REGO | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-REGR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-REAQ | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-ORRE | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-OROR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-ORGO | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GORE | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GOOR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GOGO | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GOGR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GRRE | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GROR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GRGO | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GRGR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-AQRE | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-AQOR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-AQGO | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-AQGR | 20 (40 μL) | 200 μL |
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| TOX3-HEYL-20-AQAQ | 20 (40 μL) | 200 μL |
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HEYL Gene Summary
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Hes Related Family BHLH Transcription Factor With YRPW Motif-like
Chromosome: CHR1: 40089102 -40105348
Locus: 1p34.2
TOX3 Gene Summary
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Gene Name: TOX High Mobility Group Box Family Member 3
Chromosome: CHR16: 52471917 -52581714
Locus: 16q12.1
Gene Diseases
The TOX3 HEYL Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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