TOPORS-ADAMTSL1 Fusion FISH Probe
The TOPORS-ADAMTSL1 Fusion FISH Probe is used to confirm a fusion of the TOPORS and ADAMTSL1 genes. The fusion of the TOPORS and ADAMTSL1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOPORS-ADAMTSL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-RERE | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-REOR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-REGO | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-REGR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-REAQ | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-ORRE | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-OROR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-ORGO | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GORE | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GOOR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GOGO | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GOGR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GRRE | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GROR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GRGO | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GRGR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-AQRE | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-AQOR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-AQGO | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-AQGR | 20 (40 μL) | 200 μL |
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| TOPORS-ADAMTSL1-20-AQAQ | 20 (40 μL) | 200 μL |
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TOPORS Gene Summary
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Gene Name: TOP1 Binding Arginine/serine Rich Protein
Chromosome: CHR9: 32540541 -32552626
Locus: 9p21.1
ADAMTSL1 Gene Summary
This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Gene Name: ADAMTS Like 1
Chromosome: CHR9: 18474078 -18910947
Locus: 9p22.2-p22.1
Gene Diseases
The TOPORS ADAMTSL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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