TOPBP1-SPDEF Fusion FISH Probe
The TOPBP1-SPDEF Fusion FISH Probe is used to confirm a fusion of the TOPBP1 and SPDEF genes. The fusion of the TOPBP1 and SPDEF genes has been associated with Sarcoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOPBP1-SPDEF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-RERE | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-REOR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-REGO | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-REGR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-REAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-ORRE | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-OROR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-ORGO | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GORE | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GOOR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GOGO | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GOGR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GRRE | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GROR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GRGO | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GRGR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-AQRE | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-AQOR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-AQGO | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-AQGR | 20 (40 μL) | 200 μL |
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| TOPBP1-SPDEF-20-AQAQ | 20 (40 μL) | 200 μL |
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TOPBP1 Gene Summary
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Gene Name: DNA Topoisomerase II Binding Protein 1
Chromosome: CHR3: 133319448 -133380737
Locus: 3q22.1
SPDEF Gene Summary
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: SAM Pointed Domain Containing ETS Transcription Factor
Chromosome: CHR6: 34505579 -34524091
Locus: 6p21.31
Gene Diseases
The TOPBP1 SPDEF Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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