TOPBP1-NEK11 Fusion FISH Probe
The TOPBP1-NEK11 Fusion FISH Probe is used to confirm a fusion of the TOPBP1 and NEK11 genes. The fusion of the TOPBP1 and NEK11 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOPBP1-NEK11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-RERE | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-REOR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-REGO | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-REGR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-REAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-ORRE | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-OROR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-ORGO | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GORE | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GOOR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GOGO | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GOGR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GRRE | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GROR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GRGO | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GRGR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-AQRE | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-AQOR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-AQGO | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-AQGR | 20 (40 μL) | 200 μL |
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| TOPBP1-NEK11-20-AQAQ | 20 (40 μL) | 200 μL |
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TOPBP1 Gene Summary
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Gene Name: DNA Topoisomerase II Binding Protein 1
Chromosome: CHR3: 133319448 -133380737
Locus: 3q22.1
NEK11 Gene Summary
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Gene Name: NIMA Related Kinase 11
Chromosome: CHR3: 130745693 -131069309
Locus: 3q22.1
Gene Diseases
The TOPBP1 NEK11 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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