TOP3A-TEKT1 Fusion FISH Probe
The TOP3A-TEKT1 Fusion FISH Probe is used to confirm a fusion of the TOP3A and TEKT1 genes. The fusion of the TOP3A and TEKT1 genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOP3A-TEKT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-RERE | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-REOR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-REGO | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-REGR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-REAQ | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-ORRE | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-OROR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-ORGO | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GORE | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GOOR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GOGO | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GOGR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GRRE | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GROR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GRGO | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GRGR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-AQRE | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-AQOR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-AQGO | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-AQGR | 20 (40 μL) | 200 μL |
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| TOP3A-TEKT1-20-AQAQ | 20 (40 μL) | 200 μL |
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TOP3A Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Gene Name: DNA Topoisomerase III Alpha
Chromosome: CHR17: 18177234 -18218321
Locus: 17p11.2
TEKT1 Gene Summary
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Gene Name: Tektin 1
Chromosome: CHR17: 6703299 -6735060
Locus: 17p13.1
Gene Diseases
The TOP3A TEKT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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