TOP2B-NGLY1 Fusion FISH Probe
The TOP2B-NGLY1 Fusion FISH Probe is used to confirm a fusion of the TOP2B and NGLY1 genes. The fusion of the TOP2B and NGLY1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOP2B-NGLY1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-RERE | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-REOR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-REGO | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-REGR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-REAQ | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-ORRE | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-OROR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-ORGO | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GORE | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GOOR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GOGO | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GOGR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GRRE | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GROR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GRGO | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GRGR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-AQRE | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-AQOR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-AQGO | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-AQGR | 20 (40 μL) | 200 μL |
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| TOP2B-NGLY1-20-AQAQ | 20 (40 μL) | 200 μL |
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TOP2B Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: DNA Topoisomerase II Beta
Chromosome: CHR3: 25639474 -25705788
Locus: 3p24.2
NGLY1 Gene Summary
This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Name: N-glycanase 1
Chromosome: CHR3: 25760434 -25831530
Locus: 3p24.2
Gene Diseases
The TOP2B NGLY1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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