TOP1-CDH4 Fusion FISH Probe
The TOP1-CDH4 Fusion FISH Probe is used to confirm a fusion of the TOP1 and CDH4 genes. The fusion of the TOP1 and CDH4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOP1-CDH4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-RERE | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-REOR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-REGO | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-REGR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-REAQ | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-ORRE | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-OROR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-ORGO | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GORE | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GOOR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GOGO | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GOGR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GRRE | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GROR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GRGO | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GRGR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-AQRE | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-AQOR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-AQGO | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-AQGR | 20 (40 μL) | 200 μL |
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| TOP1-CDH4-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH4 Gene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Cadherin 4
Chromosome: CHR20: 59827558 -60512299
Locus: 20q13.33
TOP1 Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
Gene Name: DNA Topoisomerase I
Chromosome: CHR20: 39657461 -39753126
Locus: 20q12
Gene Diseases
The TOP1 CDH4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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