TOB2-MRPS18B Fusion FISH Probe
The TOB2-MRPS18B Fusion FISH Probe is used to confirm a fusion of the TOB2 and MRPS18B genes. The fusion of the TOB2 and MRPS18B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOB2-MRPS18B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-RERE | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-REOR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-REGO | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-REGR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-REAQ | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-ORRE | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-OROR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-ORGO | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GORE | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GOOR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GOGO | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GOGR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GRRE | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GROR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GRGO | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GRGR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-AQRE | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-AQOR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-AQGO | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-AQGR | 20 (40 μL) | 200 μL |
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| TOB2-MRPS18B-20-AQAQ | 20 (40 μL) | 200 μL |
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TOB2 Gene Summary
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]
Gene Name: Transducer Of ERBB2, 2
Chromosome: CHR22: 41829491 -41843027
Locus: 22q13.2
MRPS18B Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S18B
Chromosome: CHR6_dbb_hap3: 1879123 -1887812
Locus: 6p21.33
Gene Diseases
The TOB2 MRPS18B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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