TOB1-UTRN Fusion FISH Probe
The TOB1-UTRN Fusion FISH Probe is used to confirm a fusion of the TOB1 and UTRN genes. The fusion of the TOB1 and UTRN genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOB1-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| TOB1-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
TOB1 Gene Summary
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Transducer Of ERBB2, 1
Chromosome: CHR17: 48939586 -48945339
Locus: 17q21.33
Gene Diseases
The TOB1 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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