TNXB-DDR1 Fusion FISH Probe
The TNXB-DDR1 Fusion FISH Probe is used to confirm a fusion of the TNXB and DDR1 genes. The fusion of the TNXB and DDR1 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNXB-DDR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-RERE | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-REOR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-REGO | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-REGR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-REAQ | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-ORRE | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-OROR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-ORGO | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GORE | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GOOR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GOGO | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GOGR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GRRE | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GROR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GRGO | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GRGR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-AQRE | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-AQOR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-AQGO | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-AQGR | 20 (40 μL) | 200 μL |
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| TNXB-DDR1-20-AQAQ | 20 (40 μL) | 200 μL |
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DDR1 Gene Summary
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Discoidin Domain Receptor Tyrosine Kinase 1
Chromosome: CHR6_dbb_hap3: 2145962 -2162051
Locus: 6p21.33
TNXB Gene Summary
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Tenascin XB
Chromosome: CHR6_cox_hap2: 3479582 -3547813
Locus: 6p21.33-p21.32
Gene Diseases
The TNXB DDR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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